mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

(Cell, Vol. 123, 569–580; November 18, 2005) We, the editors of Cell, were contacted by a concerned reader regarding duplication in Figure 2 above paper. Dr. John Blenis, corresponding author, determined that error was introduced during revision manuscript. In preparing final version 2B, panel showing results for eIF3b mislabeled as HA (S6K1) lysate. A different exposure panels published Figures 2C and 2D then mistakenly used eIF3b, resulting duplication. The authors no longer have access to original data lysate 16 years ago, consequence, Correction is not possible. Given age paper does compromise conclusions paper, based on information available us at this time, we believe further action warranted. mTOR S6K1 Mediate Assembly Translation Preinitiation Complex through Dynamic Protein Interchange Ordered Phosphorylation EventsHolz et al.CellNovember 2005In BriefIn response nutrients, energy sufficiency, hormones, mitogenic agents, phosphorylates several targets linked translation. However, molecular mechanisms whereby activated, encounters substrate, contributes translation initiation are poorly understood. We show maneuver off eukaryotic factor 3 (eIF3) complex signal-dependent, choreographed fashion. When inactive, associates with eIF3 complex, while activator mTOR/raptor not. Full-Text PDF Open Archive